U.S. Department of Energy

Pacific Northwest National Laboratory

Proteomics Research Resource for Integrative Biology

A collection of cells.

The possible roles and importance of proteomics are rapidly growing across essentially all areas of biological research. The precise and comprehensive measurement of levels of expressed proteins and their modified forms can provide new insights into the molecular nature of cell-signaling pathways and networks, the cell cycle, cellular differentiation, and other processes relevant to understanding human health and the progression of various disease states. The ability to characterize protein complexes complements this capability, allowing hypotheses to be tested and the biological system operation to be defined.

However, the most advanced proteomic technologies and capabilities, mostly developmental by nature, have been largely unavailable to the biomedical research community. This Research Resource has been established to bridge that gap, by developing and integrating new proteomic technologies for collaborative and service studies, disseminating the new technologies, and training scientists in their use.

For more in-depth information, please visit the Proteomics Resource for Integrative Biology web page.


Dr. Smith's research interests span development of advanced analytical methods and instrumentation, with particular emphasis on high-resolution separations and mass spectrometry, and their applications in biological and biomedical research. Over the...
Dr. Monroe's research involves development of algorithms and software for custom and automated analysis of proteomics and bioinformatics data, including managing, summarizing, and mining the large volumes of data generated by mass spectrometry-based...
| Pacific Northwest National Laboratory