U.S. Department of Energy

Pacific Northwest National Laboratory

Omics of Lethal Human Viruses

Ebola virus.

The OMICS-LHV (Lethal Human Viruses) project uses a systems biology approach to develop a comprehensive understanding of the host response to unique viruses that cause lethal infections in humans.

Funded the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and Department of Health and Human Services, OMICS-LHV brings together six institutions: Icahn School of Medicine at Mount Sinai, the University of North Carolina at Chapel Hill, Washington University in St. Louis, Wisconsin Institute for Discovery, Wisconsin University of Madison-Wisconsin, and PNNL.

PNNL researchers are providing expertise in computational modeling, proteomics, lipidomics, and metabolomics. 

The knowledge gained from this work is expected to provide a strong foundation for understanding the host response to lethal human virus pathogens, and it could facilitate development of improved strategies for intervening with lethal virus disease.

 

Team

I received my PhD in Chemistry in the Department of Chemistry and Biochemistry at the University of South Carolina with Dr. John W. Baynes, who studied the role of the Maillard reaction in the development of diabetic complications and in aging. ...
Dr Mitchell's research involves using computational analysis of 'omics data to identify key components of biological systems. Analyses focus on network inference and topology, and involves data from a diverse array of prokaryotic and eukaryotic...
Jason is interested in the molecular pathogenesis that underlies poor clinical outcomes in viral and protozoan infectious diseases.  His current research uses cutting-edge methods in machine learning and graph analytics to translate multi-omic data...
Dr. Katrina Waters is the division director for Biological Sciences at the Pacific Northwest National Laboratory.  Waters has a Ph.D. in biochemistry and more than 15 years of experience in microarray and proteomics data analysis. Her research...
Dr. Smith's research interests span development of advanced analytical methods and instrumentation, with particular emphasis on high-resolution separations and mass spectrometry, and their applications in biological and biomedical research. Over the...
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