U.S. Department of Energy

Pacific Northwest National Laboratory

Tom Weber

Professional Title: 


  • Smith JN, ZA Carver, TJ Weber, and C Timchalk. 2017. "Predicting Transport of 3,5,6-Trichloro-2-pyridinol into Saliva Using a Combination Experimental and Computational Approach." Toxicological Sciences 157(2):438-450.  doi:10.1093/toxsci/kfx055
  • Timchalk C, TJ Weber, and JN Smith. 2017. "The Need for Non- or Minimally-Invasive Biomonitoring Strategies and the Development of Pharmacokinetic/Pharmacodynamic Models for Quantification." Current Opinion in Toxicology 4:28-34. doi:10.1016/j.cotox.2017.03.003


  • Tilton SC, MM Matzke, MB Sowa, DL Stenoien, TJ Weber, WF Morgan, and KM Waters. 2015. "Data Integration Reveals Key Homeostatic Mechanisms Following Low Dose Radiation Exposure." Toxicology and Applied Pharmacology 285(2):1-11. doi:10.1016/j.taap.2015.01.019
  • Timchalk C, TJ Weber, and JN Smith. 2015. "Computational Strategy for Quantifying Human Pesticide Exposure based upon a Saliva Measurement." Frontiers in Pharmacology 6:Article No. 115.  doi:10.3389/fphar.2015.00115
  • Wright AT, T Magnaldo, RL Sontag, LN Anderson, NC Sadler, PD Piehowski, Y Gache, and TJ Weber. 2015. "Deficient Expression of Aldehyde Dehydrogenase 1A1 Is Consistent with Increased Sensitivity of Gorlin Syndrome Patients to Radiation Carcinogenesis." Molecular Carcinogenesis 54(6):473-484.  doi:10.1002/mc.22115


  • Genetos DC, A Wong, TJ Weber, NJ Karin, and CE Yellowley. 2014. "Impaired osteoblast differentiation in Annexin A2- and -A5-deficient cells." PLoS One 9(9):Article No. e107482. doi:10.1371/journal.pone.0107482
  • Waters KM, BS Cummings, H Shankaran, NE Scholpa, and TJ Weber. 2014. "ERK Oscillation-Dependent Gene Expression Patterns and Deregulation by Stress-Response." Chemical Research in Toxicology 27(9):1496-1503.  doi:10.1021/tx500085u


  • Wang Y, Z Li, TJ Weber, D Hu, CT Lin, J Li, and Y Lin. 2013. "In Situ Live Cell Sensing of Multiple Nucleotides Exploiting DNA/RNA Aptamers and Graphene Oxide Nanosheets." Analytical Chemistry 85(14):6775-6782.  doi:10.1021/ac400858g
  • Waters KM, RL Sontag, and TJ Weber. 2013. "Hepatic Leukemia Factor Promotes Resistance To Cell Death: Implications For Therapeutics and Chronotherapy." Toxicology and Applied Pharmacology 268(2):141-148.  doi:10.1016/j.taap.2013.01.031


  • Shankaran H, TJ Weber, CH Freiin von Neubeck, and MB Sowa. 2012. "Using Imaging Methods to Interrogate Radiation-Induced Cell Signaling." Radiation Research 177(4 ):496-507.  doi:10.1667/RR2669.1
  • Sontag RL, and TJ Weber. 2012. "Ectopic ERK Expression Induces Phenotypic Conversion of C10 Cells and Alters DNA Methyltransferase Expression." BMC Research Notes 5:Article No. 217.  doi:10.1186/1756-0500-5-217
  • Waters KM, DL Stenoien, MB Sowa, CH Freiin Von Neubeck, WB Chrisler, R Tan, RL Sontag, and TJ Weber. 2012. "Annexin A2 Modulates Radiation-Sensitive Transcriptional Programming and Cell Fate." Radiation Research 179(1):56-61.  doi:10.1667/RR3056.1
  • Waters KM, T Liu, RD Quesenberry, AR Willse, S Bandyopadhyay, LE Kathmann, TJ Weber, RD Smith, HS Wiley, and BD Thrall. 2012. "Network Analysis of Epidermal Growth Factor Signaling using Integrated Genomic, Proteomic and Phosphorylation Data ." PLoS One 7(3):Article No. e34515.  doi:10.1371/journal.pone.0034515


  • Zangar RC, N Bollinger, TJ Weber, R Tan, LM Markillie, and NJ Karin. 2011. "Reactive Oxygen Species Alter Autocrine and Paracrine Signaling." Free Radical Biology & Medicine 51(11):2041-2047.  doi:10.1016/j.freeradbiomed.2011.09.001


  • Shankaran H, WB Chrisler, RL Sontag, and TJ Weber. 2010. "Inhibition of ERK Oscillations by Ionizing Radiation and Reactive Oxygen Species." Molecular Carcinogenesis 50(6):424-432. doi:10.1002/mc.20724
  • Weber TJ, H Shankaran, HS Wiley, LK Opresko, WB Chrisler, and RD Quesenberry. 2010. "Basic Fibroblast Growth Factor Regulates Persistent ERK Osciliations in Premaligant but not Malignant JB6 Cells." Journal of Investigative Dermatology 130(5):144-156. 


  • Waters KM, R Tan, LK Opresko, RD Quesenberry, S Bandyopadhyay, WB Chrisler, and TJ Weber. 2009. "Cellular Dichotomy Between Anchorage-Independent Growth Responses to bFGF and TA Reflects Molecular Switch in Commitment to Carcinogenesis." Molecular Carcinogenesis 48(11):1059-1069. 
  • Weber TJ, LK Opresko, DM Waisman, GJ Newton, RD Quesenberry, N Bollinger, RJ Moore, and RD Smith. 2009. "Regulation of the Low Dose Radiation Paracrine-Specific Anchorage-Independent Growth Response by Annexin A2." Radiation Research 172(1):96-105. doi:10.1667/RR1220.1


  • Sweeney LM, KD Thrall, TS Poet, R Corley, TJ Weber, BJ Locey, J Clarkson, S Sager, and ML Gargas. 2008. "Physiologically based Pharmacokinetic Modeling of 1,4-Dioxane in Rats, Mice, and Humans." Toxicological Sciences 101(1):32-50.  doi:10.1093/toxsci/kfm251 


  • Dutta D, SK Sundaram, JG Teeguarden, BJ Riley, LS Fifield, JM Jacobs, RS Addleman, GA Kaysen, BM Moudgil, and TJ Weber. 2007. "Adsorbed Proteins Influence the Biological Activity and Molecular Targeting of Nanomaterials." Toxicological Sciences 100(1):303-315. doi:10.1093/toxsci/kfm217 


  • Weber TJ, HS Smallwood, LE Kathmann, LM Markillie, TC Squier, and BD Thrall. 2006. "Functional link between TNF biosynthesis and CaM-dependent activation of inducible nitric oxide synthase in RAW 264.7 macrophages ." American Journal of Physiology. Cell Physiology 290(6):C1512-C1520.  doi:10.1152/ajpcell.00527.2005 


  • Weber TJ, RW Siegel, LM Markillie, WB Chrisler, XC Lei, and NH Colburn. 2005. "A paracrine signal mediates the cell transformation response to low dose gamma radiation in JB6 cells ." Molecular Carcinogenesis 43(1):31-37. 


  • Weber TJ, S Negash, HS Smallwood, KS Ramos, BD Thrall, and TC Squier. 2004. "Calmodulin Involvement in Stress-Activated Nuclear Localization of Albumin in JB6 Epithelial Cells." Biochemistry 43(23):7443-7450. 


  • Weber TJ, and LM Markillie. 2003. "Regulation of Activator Protein-1 by 8-iso-Prostaglandin E2 in a Thromboxane A2 Receptor-Dependent and -Independent Manner ." Molecular Pharmacology 63(5):1075-81. 
  • Weber TJ, and LM Markillie. 2003. "Regulation of activator protein-1 by 8-iso-prostaglandin E2 in a thromboxane A2 receptor-dependent and -independent manner." Molecular Pharmacology 63(5):1075-1081. 


  • Majors PD, KR Minard, EJ Ackerman, GR Holtom, DF Hopkins, CI Parkinson, TJ Weber, and RA Wind. 2002. "A combined confocal and magnetic resonance microscope for biological studies." Review of Scientific Instruments 73(12):4329-4338. 
  • Weber TJ, LM Markillie, WB Chrisler, GA Vielhauer, and JW Regan. 2002. "Modulation of JB6 Mouse Epidermal Cell Transformation Response by the Prostaglandin F2 alpha Receptor." Molecular Carcinogenesis 35(4):163-172. 
  • Weber TJ, LM Markillie, WB Chrisler, GA Vielhauer, and JW Regan. 2002. "Modulation of JB6 Mouse Epidermal Cell Transformation Response by the Prostaglandin F2 Alpha Receptor." Molecular Carcinogenesis 35(4):163-172. 
  • Wind RA, PD Majors, KR Minard, EJ Ackerman, DS Daly, GR Holtom, BD Thrall, and TJ Weber. 2002. "Combined Confocal and Magnetic Resonance Microscopy." Applied Magnetic Resonance 22(2):145-158. 


  • Weber TJ, Q Huang, TJ Monks, and SS Lau. 2001. "Differential Regulation of Redox Responsive Transcription Factors by the Nephrocarcinogen 2,3,5-tris(glutathion-S-yl)hydroquinone." Chemical Research in Toxicology 14(7):814-821. 


  • Weber TJ, TJ Monks, and SS Lau. 2000. " DDM-PGE(2)-mediated cytoprotection in renal epithelial cells by a thromboxane A(2) receptor coupled to NF-kappaB." American Journal of Physiology. Cell Physiology 278(2):F270-278. 
  • Towndrow KM, JJ Mertens, JK Jeong, TJ Weber, TJ Monks, and SS Lau. 2000. "Stress- and growth-related gene expression are independent of chemical-induced prostaglandin E(2) synthesis in renal epithelial cells." Chemical Research in Toxicology 13(2):111-117. 
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