U.S. Department of Energy

Pacific Northwest National Laboratory

Lindsey Anderson

Lindsey Anderson
Professional Title: 
Scientist
Email: 
lindsey.anderson@pnnl.gov
Biography: 

Lindsey Anderson’s research has been dedicated to the identification and characterization of novel, targeted and non-targeted, functional metabolic interactions using a high-throughput systems biology and computational biology approach. Her expertise in functional metabolism and multidisciplinary data integration stems from a research background in biochemistry, molecular/cellular biology, activity-based protein profiling (ABPP), proteomics, and multi-Omics data analysis (proteomic, metabolomic, lipidomic, and transcriptomic data) in a diverse set of biological systems. Lindsey's current research has focused around advancing high sensitivity omics data processing and dissemination, combining modern bioinformatic techniques with innovative analytical/computational tools optimized for high-throughput data integration, visualization, and biological interpretation.

Research Interests: 
  • Multi-Omics Data Analysis 
  • Functional Metabolism/Biochemical Pathway Analysis
  • Undiagnosed, Inherited Metabolic Disease
  • Exposure/Xenobiotic Metabolism
  • Activity-Based Protein Profiling 
  • Microbial Interactions/Microbiomes
  • Infectious Disease and Pathogenesis
Publications: 

2019

  • Lin VS, Volk RF, DeLeon AJ, Anderson LN, Purvine SO, Shukla AK, Bernstein HC, Smith JN, Wright AT. "Structure dependent determination of organophosphate targets in mammalian tissues using activity-based protein profiling." Chem Res Toxicol. 2019 Dec 24. doi: 10.1021/acs.chemrestox.9b00344
  • Merkley ED, KE Burnum-Johnson, LN Anderson, SC Jenson, and KL Wahl. "Uniformly 15N-Labeled Recombinant Ricin A-chain as an Internal Retention Time Standard for Increased Confidence in Forensic Identification of Ricin by Untargeted Nanoflow Liquid Chromatog-raphy-Tandem Mass Spectrometry." Analytical Chemistry. 2019 Oct 22. doi: 10.1021/acs.analchem.9b03389
  • Dickinson M, LN Anderson, BM Webb-Robertson, JR Hansen, RD Smith, AT Wright, and K Hybiske. "Proximity-dependent proteomics of the Chlamydia trachomatis inclusion membrane reveals functional interactions with endoplasmic reticulum exit sites." PLoS Pathogens. 2019 Apr 3; 15(4):e1007698. doi:10.1371/journal.ppat.1007698

2018

  • Ortega C, A Frando, BJM Webb-Robertson, LN Anderson, N Fleck, EL Flannery, M Fishbaugher, TA Murphree, JR Hansen, RD Smith, SH Kappe, AT Wright, and C Grunder. 2018. "A global survey of ATPase activity in Plasmodium falciparum asexual blood stages and gametocytes." Molecular and Cellular Proteomics 17(1):111-120. doi:10.1074/mcp.RA117.000088

2017

  • Romine MF, DA Rodionov, Y Maezato, LN Anderson, P Nandhikonda, IA Rodionova, A Carre, X Li, C Xu, TRW Clauss, YM Kim, TO Metz, and AT Wright. 2017. "Elucidation of new roles for vitamin B12 in regulation of folate, ubiquinone, and methionine metabolism." Proceedings of the National Academy of Sciences of the United States of America 114(7):E1205-E1214. doi:10.1073/pnas.1612360114

https://www.pnnl.gov/science/highlights/highlight.asp?id=4526

  • Rosnow JJ, LN Anderson, RN Nair, ES Baker, and AT Wright. 2017. "Emerging Multi-Omic Technologies for Improved Functional Characterization of Lignocellulose Degrading Enzymes." Critical Reviews in Biotechnology 37(5):626-640. doi:10.1080/07388551.2016.1209158

2016

  • Anderson LN, PK Koech, AE Plymale, EV Landorf , A Konopka, F Collart, MS Lipton, MF Romine, and AT Wright. 2016. "Live Cell Discovery of Microbial Vitamin Transport and Enzyme-Cofactor Interactions." ACS Chemical Biology 11(2):345-354. doi:10.1021/acschembio.5b00918

Featured Journal Cover

https://www.pnnl.gov/science/highlights/highlight.asp?id=4190

  • Ortega C, LN Anderson, A Frando, NC Sadler, RW Brown, RD Smith, AT Wright, and C Grundner. 2016. "Systematic Survey of Serine Hydrolase Activity in Mycobacterium tuberculosis Defines Changes Associated with Persistence." Cell Chemical Biology 23(2):290-298.  doi:10.1016/j.chembiol.2016.01.003
  • Sadler NC, HC Bernstein, MR Melnicki, MA Charania, EA Hill, LN Anderson, ME Monroe, RD Smith, AS Beliaev, and AT Wright. 2016. "Dinitrogenase Driven Photobiological Hydrogen Production Combats Oxidative Stress in Cyanothece sp. ATCC 51142." Applied Environmental Microbiology 82(24):7227-7235.  doi:10.1128/AEM.02098-16
  • Sadler NC, P Nandhikonda, BJM Webb-Robertson, C Ansong, LN Anderson, JN Smith, RA Corley, and AT Wright. 2016. "Hepatic cytochrome P450 activity, abundance, and expression throughout human development." Drug Metabolism and Disposition 44(7):984-91. doi:10.1124/dmd.115.068593

2015

  • Wright AT, T Magnaldo, RL Sontag, LN Anderson, NC Sadler, PD Piehowski, Y Gache, and TJ Weber. 2015. "Deficient Expression of Aldehyde Dehydrogenase 1A1 Is Consistent with Increased Sensitivity of Gorlin Syndrome Patients to Radiation Carcinogenesis." Molecular Carcinogenesis 54(6):473-484.  doi:10.1002/mc.22115

2014

  • Wiedner SD, LN Anderson, NC Sadler, WB Chrisler, VK Kodali, RD Smith, and AT Wright. 2014. "Organelle-Specific Activity-Based Protein Profiling in Living Cells." Angewandte Chemie International Edition 53(11):2919-2922. doi:10.1002/anie.201309135

https://www.pnnl.gov/science/highlights/highlight.asp?id=1628

  • Ortega C, R Liao, LN Anderson, T Rustad, AR Ollodart, AT Wright, DR Sherman, and C Grundner. 2014. "Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch." PLoS Biology 12(1):Article No. e1001746. doi:10.1371/journal.pbio.1001746

2013

  • Anderson LN, DE Culley, BA Hofstad, LM Chauvigne-Hines, EM Zink, SO Purvine, RD Smith, SJ Callister, JM Magnuson, and AT Wright. 2013. "Activity-based protein profiling of secreted cellulolytic enzyme activity dynamics in Trichoderma reesei QM6a, NG14, and RUT-C30." Molecular Biosystems 9(12):2992-3000.  doi:10.1039/c3mb70333a

Featured Journal Cover

https://www.pnnl.gov/science/highlights/highlight.asp?id=1503

2012

  • Wiedner SD, KE Burnum, LM Pederson, LN Anderson, S Fortuin, LM Chauvigne-Hines, AK Shukla, C Ansong, EA Panisko, RD Smith, and AT Wright. 2012. "Multiplexed Activity-based Protein Profiling of the Human Pathogen Aspergillus fumigatus Reveals Large Functional Changes upon Exposure to Human Serum." Journal of Biological Chemistry 287(40):33447-33459.  doi:10.1074/jbc.M112.394106
  • Chauvigne-Hines LM, LN Anderson, HM Weaver, JN Brown, PK Koech, CD Nicora, BA Hofstad, RD Smith, MJ Wilkins, SJ Callister, and AT Wright. 2012. "Suite of Activity-Based Probes for Cellulose-Degrading Enzymes." Journal of the American Chemical Society 134(50):20521-20532.  doi:10.1021/ja309790w

https://www.pnnl.gov/science/highlights/highlight.asp?id=1304

  • Wiedner SD, KE Burnum, LM Pederson, LN Anderson, S Fortuin, LM Chauvigne-Hines, AK Shukla, C Ansong, EA Panisko, RD Smith, and AT Wright. 2012. "Multiplexed Activity-Based Protein Profiling of the Human Pathogen Aspergillus fumigatus Reveals Large Functional Changes Upon Exposure to Human Serum." Journal of Biological Chemistry 287(40):33447-33459.  doi:10.1074/jbc.M112.394106

https://www.pnnl.gov/science/highlights/highlight.asp?id=1266

 

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