U.S. Department of Energy

Pacific Northwest National Laboratory

Lindsey Anderson

Lindsey Anderson
Professional Title: 
Scientist
Email: 
lindsey.anderson@pnnl.gov
Biography: 

Lindsey Anderson’s research has been dedicated to the characterization and identification of novel metabolic functional interactions using a high-throughput systems biology and chemical biology approach. Her expertise in metabolism and multidisciplinary data integration stems from her background in both experimental (targeted molecular/cellular biology) and computational research in a diverse set of biological systems. Her current research is focused around integrating mass spectrometry-based multi-omic experimental data with modern metabolic modeling and bioinformatic techniques for high-throughput data integration, biological interpretation, and visualization in a collaborative setting.

Publications: 

2018

  • Ortega C, A Frando, BJM Webb-Robertson, LN Anderson, N Fleck, EL Flannery, M Fishbaugher, TA Murphree, JR Hansen, RD Smith, SH Kappe, AT Wright, and C Grunder. 2018. "A global survey of ATPase activity in Plasmodium falciparum asexual blood stages and gametocytes." Molecular and Cellular Proteomics 17(1):111-120. doi:10.1074/mcp.RA117.000088

2017

  • Romine MF, DA Rodionov, Y Maezato, LN Anderson, P Nandhikonda, IA Rodionova, A Carre, X Li, C Xu, TRW Clauss, YM Kim, TO Metz, and AT Wright. 2017. "Elucidation of new roles for vitamin B12 in regulation of folate, ubiquinone, and methionine metabolism." Proceedings of the National Academy of Sciences of the United States of America 114(7):E1205-E1214. doi:10.1073/pnas.1612360114
  • Rosnow JJ, LN Anderson, RN Nair, ES Baker, and AT Wright. 2017. "Emerging Multi-Omic Technologies for Improved Functional Characterization of Lignocellulose Degrading Enzymes." Critical Reviews in Biotechnology 37(5):626-640. doi:10.1080/07388551.2016.1209158

2016

  • Anderson LN, PK Koech, AE Plymale, EV Landorf , A Konopka, F Collart, MS Lipton, MF Romine, and AT Wright. 2016. "Live Cell Discovery of Microbial Vitamin Transport and Enzyme-Cofactor Interactions." ACS Chemical Biology 11(2):345-354. doi:10.1021/acschembio.5b00918
  • Ortega C, LN Anderson, A Frando, NC Sadler, RW Brown, RD Smith, AT Wright, and C Grundner. 2016. "Systematic Survey of Serine Hydrolase Activity in Mycobacterium tuberculosis Defines Changes Associated with Persistence." Cell Chemical Biology 23(2):290-298.  doi:10.1016/j.chembiol.2016.01.003
  • Sadler NC, HC Bernstein, MR Melnicki, MA Charania, EA Hill, LN Anderson, ME Monroe, RD Smith, AS Beliaev, and AT Wright. 2016. "Dinitrogenase Driven Photobiological Hydrogen Production Combats Oxidative Stress in Cyanothece sp. ATCC 51142." Applied Environmental Microbiology 82(24):7227-7235.  doi:10.1128/AEM.02098-16
  • Sadler NC, P Nandhikonda, BJM Webb-Robertson, C Ansong, LN Anderson, JN Smith, RA Corley, and AT Wright. 2016. "Hepatic cytochrome P450 activity, abundance, and expression throughout human development." Drug Metabolism and Disposition 44(7):984-91. doi:10.1124/dmd.115.068593

2015

  • Wright AT, T Magnaldo, RL Sontag, LN Anderson, NC Sadler, PD Piehowski, Y Gache, and TJ Weber. 2015. "Deficient Expression of Aldehyde Dehydrogenase 1A1 Is Consistent with Increased Sensitivity of Gorlin Syndrome Patients to Radiation Carcinogenesis." Molecular Carcinogenesis 54(6):473-484.  doi:10.1002/mc.22115

2014

  • Wiedner SD, LN Anderson, NC Sadler, WB Chrisler, VK Kodali, RD Smith, and AT Wright. 2014. "Organelle-Specific Activity-Based Protein Profiling in Living Cells." Angewandte Chemie International Edition 53(11):2919-2922. doi:10.1002/anie.201309135
  • Ortega C, R Liao, LN Anderson, T Rustad, AR Ollodart, AT Wright, DR Sherman, and C Grundner. 2014. "Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch." PLoS Biology 12(1):Article No. e1001746. doi:10.1371/journal.pbio.1001746

2013

  • Anderson LN, DE Culley, BA Hofstad, LM Chauvigne-Hines, EM Zink, SO Purvine, RD Smith, SJ Callister, JM Magnuson, and AT Wright. 2013. "Activity-based protein profiling of secreted cellulolytic enzyme activity dynamics in Trichoderma reesei QM6a, NG14, and RUT-C30." Molecular Biosystems 9(12):2992-3000.  doi:10.1039/c3mb70333a

2012

  • Wiedner SD, KE Burnum, LM Pederson, LN Anderson, S Fortuin, LM Chauvigne-Hines, AK Shukla, C Ansong, EA Panisko, RD Smith, and AT Wright. 2012. "Multiplexed Activity-based Protein Profiling of the Human Pathogen Aspergillus fumigatus Reveals Large Functional Changes upon Exposure to Human Serum." Journal of Biological Chemistry 287(40):33447-33459.  doi:10.1074/jbc.M112.394106
  • Chauvigne-Hines LM, LN Anderson, HM Weaver, JN Brown, PK Koech, CD Nicora, BA Hofstad, RD Smith, MJ Wilkins, SJ Callister, and AT Wright. 2012. "Suite of Activity-Based Probes for Cellulose-Degrading Enzymes." Journal of the American Chemical Society 134(50):20521-20532.  doi:10.1021/ja309790w
  • Wiedner SD, KE Burnum, LM Pederson, LN Anderson, S Fortuin, LM Chauvigne-Hines, AK Shukla, C Ansong, EA Panisko, RD Smith, and AT Wright. 2012. "Multiplexed Activity-Based Protein Profiling of the Human Pathogen Aspergillus fumigatus Reveals Large Functional Changes Upon Exposure to Human Serum." Journal of Biological Chemistry 287(40):33447-33459.  doi:10.1074/jbc.M112.394106
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