U.S. Department of Energy

Pacific Northwest National Laboratory

Justin Teeguarden

Justin Teeguarden
Professional Title: 
Scientist & Team Lead


  • Davie-Martin CL, KG Stratton, JG Teeguarden, KM Waters, and SL Massey Simonich. 2017. "Implications of bioremediation of polycyclic aromatic hydrocarbon-contaminated soils for human health and cancer risk." Environmental Science & Technology 51(17):9458-9468.  doi:10.1021/acs.est.7b02956
  • Ma J, CP Casey, X Zheng, YM Ibrahim, CS Wilkins, RS Renslow, DG Thomas, SH Payne, ME Monroe, RD Smith, JG Teeguarden, EM Baker, and TO Metz. 2017. "PIXiE: An Algorithm for Automated Ion Mobility Arrival Time Extraction and Collision Cross Section Calculation using Global Data Association." Bioinformatics 33(17):2715-2722. doi:10.1093/bioinformatics/btx305
  • Metz TO, EM Baker, EL Schymanski, RS Renslow, DG Thomas, TJ Causon, IK Webb, S Hann, RD Smith, and JG Teeguarden. 2017. "Integrating Ion Mobility Spectrometry into Mass Spectrometry-based Exposome Measurements: What Can It Add and How Far Can It Go?" Bioanalysis 9(1):81-98.  doi:10.4155/bio-2016-0244


  • Teeguarden JG, YM Tan, S Edwards, JA Leonard, K Anderson, RA Corley, ML Kile, SL Massey Simonich, D Stone, R Tanguay, KM Waters, S Harper, and DE Williams. 2016. "Expanding on Successful Concepts, Models, and Organization." Environmental Science & Technology 50(17):8921-8922.  doi:10.1021/acs.est.6b03027
  • Teeguarden JG, YM Tan, S Edwards, JA Leonard, KA Anderson, RA Corley, ML Kile, SL Simonich, D Stone, R Tanguay, KM Waters, S Harper, and DE Williams. 2016. "Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework." Environmental Science & Technology 50(9):4579-4586.  doi:10.1021/acs.est.5b05311
  • Kabilan S, SR Suffield, KP Recknagle, RE Jacob, DR Einstein, AP Kuprat, JP Carson, SM Colby, JH Saunders, S Hines, JG Teeguarden, TM Straub, M Moe, S Taft, and RA Corley. 2016. "Computational Fluid Dynamics Modeling of Bacillus anthracis Spore Deposition in Rabbit and Human Respiratory Airways." Journal of Aerosol Science 99:64-77. doi:10.1016/j.jaerosci.2016.01.011
  • Kabilan S, SR Suffield, KP Recknagle, RE Jacob, DR Einstein, AP Kuprat, JP Carson, SM Colby, JH Saunders, S Hines, JG Teeguarden, TM Straub, M Moe, S Taft, and RA Corley. 2016. "Computational fluid dynamics modeling of Bacillus anthracis spore deposition in rabbit and human respiratory airways." Journal of Aerosol Science 99:64-77. doi:10.1016/j.jaerosci.2016.01.011
  • Zhang X, MV Romm, X Zheng, EM Zink, YM Kim, KE Burnum-Johnson, DJ Orton, A Apffel, YM Ibrahim, ME Monroe, RJ Moore, JN Smith, J Ma, RS Renslow, DG Thomas, A Blackwell, G Swinford, J Sausen, RT Kurulugama Lekamlage, N Eno, E Darland, G Stafford, JC Fjeldsted, TO Metz, JG Teeguarden, RD Smith, and ES Baker. 2016. "SPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in bio?uids." Clinical Mass Spectrometry 2:1-10.  doi:10.1016/j.clinms.2016.11.002




  • Cohen J, JG Teeguarden, and P Demokritou. 2014. "An integrated approach for the in vitro dosimetry of engineered nanomaterials." Particle and Fibre Toxicology 11:Article No. 20. doi:10.1186/1743-8977-11-20
  • LaKind JS, JR Sobus, M Goodman, DB Barr, P Furst, RJ Albertini, TE Arbuckle, G Schoeters, YM Tan, JG Teeguarden, R Tormero-Velz, and CP Weisel. 2014. "A Proposal for Assessing Study Quality: Biomonitoring, Environmental Epidemiology, and Short-Lived Chemicals (BEES-C) Instrument ." Environment International 73:195-207. doi:10.1016/j.envint.2014.07.011
  • Larson JK, MJ Carvan, JG Teeguarden, G Watanabe, K Taya, E Krystofiak, and RJ Hutz. 2014. "Low-dose gold nanoparticles exert subtle endocrine-modulating effects on the ovarian steroidogenic pathway ex vivo independent of oxidative stress." Nanotoxicology 8(8):856-66.  doi:10.3109/17435390.2013.837208
  • Teeguarden JG, VB Mikheev, KR Minard, WC Forsythe, W Wang, G Sharma, NJ Karin, SC Tilton, KM Waters, B Asgharian, O Price, JG Pounds, and BD Thrall. 2014. "Comparative Iron Oxide Nanoparticle Cellular Dosimetry and Response in Mice by the Inhalation and Liquid Cell Culture Exposure Routes." Particle and Fibre Toxicology 11:Article No. 46. doi:10.1186/s12989-014-0046-4


  • Shankaran H, F Adeshina, and JG Teeguarden. 2013. "Physiologically-Based Pharmacokinetic Model for Fentanyl in Support of the Development of Provisional Advisory Levels." Toxicology and Applied Pharmacology 273(13):002464-476. doi:10.1016/j.taap.2013.05.024
  • Teeguarden JG, and S Hanson-Drury. 2013. "A Systematic Review of Bisphenol A “Low Dose” Studies in the Context of Human Exposure: A Case for Establishing Standards for Reporting “Low- Dose” Effects of Chemicals." Food and Chemical Toxicology 62:935-948. doi:10.1016/j.fct.2013.07.007
  • Teeguarden JG, C Housand, JN Smith, PM Hinderliter, R Gunawan, and C Timchalk. 2013. "A Multi-Route Model of Nicotine-Cotinine Pharmacokinetics, Pharmacodynamics and Brain Nicotinic Acetylcholine Receptor Binding in Humans." Regulatory Toxicology and Pharmacology 65(1):12-28.  doi:10.1016/J.YRTPH.2012.10.007
  • Teeguarden JG, J Fisher, and DR Doerge. 2013. "Exposure Conditions and Pharmacokinetic Principles: Interpreting Bisphenol A Absorption in the Canine Oral Cavity." Environmental Health Perspectives 121(11-12):A323-A323.  doi:10.1289/ehp.1307424 
  • Teeguarden JG, S Hanson-Drury, JW Fisher, and DR Doerge. 2013. "Are Typical Human Serum BPA Concentrations Measureable and Sufficient to be Estrogenic in the General Population?" Food and Chemical Toxicology 62:949-963.  doi:10.1016/j.fct.2013.08.001
  • DeWoskin RD, LM Sweeney, JG Teeguarden, R Sams, and J Vandenberg. 2013. "Comparison of PBTK Model and Biomarker Based Estimates of the Internal Dosimetry of Acrylamide." Food and Chemical Toxicology 58:506-521.  doi:10.1016/j.fct.2013.05.008
  • Kodali VK, MH Littke, SC Tilton, JG Teeguarden, L Shi, CW Frevert, W Wang, JG Pounds, and BD Thrall. 2013. "Dysregulation of Macrophage Activation Profiles by Engineered Nanoparticles." ACS Nano 7(8):6997-7010.  doi:10.1021/nn402145t
  • Minard KR, MH Littke, W Wang, Y Xiong, JG Teeguarden, and BD Thrall. 2013. "Magnetic Particle Detection (MPD) for In-Vitro Dosimetry." Biosensors and Bioelectronics 43:88-93. doi:10.1016/j.bios.2012.12.011
  • Sharma G, VK Kodali, MJ Gaffrey, W Wang, KR Minard, NJ Karin, JG Teeguarden, and BD Thrall. 2013. "Iron Oxide Nanoparticle Agglomeration Influences Dose-Rates and Modulates Oxidative Stress Mediated Dose-Response Profiles In Vitro." Nanotoxicology 8(6):663-675. doi:10.3109/17435390.2013.822115


  • Teeguarden JG, A Calafat, and DR Doerge. 2012. "Adhering to Fundamental Principles of Biomonitoring, BPA Pharmacokinetics, and Mass Balance is no "Flaw"." Toxicological Sciences 125(1):321-325.  doi:10.1093/toxsci/kfr275 
  • Karakoti AS, P Munusamy, KE Hostetler, VK Kodali, SVNT Kuchibhatla, G Orr, JG Pounds, JG Teeguarden, BD Thrall, and DR Baer. 2012. "Preparation and Characterization Challenges to Understanding Environmental and Biological Impacts of Ceria Nanoparticles." Surface and Interface Analysis 44(8):881-889.  doi:10.1002/sia.5006
  • Thrall BD, KR Minard, JG Teeguarden, and KM Waters. 2012. Multiscale Toxicology - Building the Next Generation Tools for Toxicology. PNNL-21916, Pacific Northwest National Laboratory, Richland, WA. 
  • Xie Y, NG Williams, A Tolic, WB Chrisler, JG Teeguarden, BL Maddux, JG Pounds, A Laskin, and G Orr. 2012. "Aerosolized ZnO nanoparticles induce toxicity in alveolar type II epithelial cells at the air-liquid interface." Toxicological Sciences 125(2):450-461. doi:10.1093/toxsci/kfr251 


  • Teeguarden JG, A Calafat, X Ye, DR Doerge, MI Churchwell, R Gunawan, and MK Graham. 2011. "Twenty-Four Hour Human Urine and Serum Profiles of Bisphenol A during High-Dietary Exposure." Toxicological Sciences 123(1):48-57.  doi:10.1093/toxsci/kfr160
  • Baer DR, AS Karakoti, P Munusamy, BD Thrall, JG Pounds, JG Teeguarden, JE Amonette, G Orr, PG Tratnyek, and JT Nurmi. 2011. "Testing in EHS: What is the Current Status of Experimentation?" In 11th IEEE International Conference on Nanotechnology (IEEE-NANO 2011), August 15-18, 2011, Portland, Oregon, pp. 18-19.  IEEE, Piscataway, NJ. doi:10.1109/NANO.2011.6144671 
  • Hanns-Rudolf P, FR Cassee, JG Teeguarden, H Fissan, S Diabate, M Aufderheide, WG Kreyling, O Hanninen, G Kasper, M Riediker, B Rothen-Rutishauser, and O Schmid. 2011. "In-vitro Cell Exposure Studies for the Assessment of Nanoparticle Toxicity in the Lung - A Dialogue between Aerosol Science and Biology." Journal of Aerosol Science 42(10):668-692. doi:10.1016/j.jaerosci.2011.06.005
  • Teeguarden JG, BJM Webb-Robertson, KM Waters, A Murray, E Kisin, SM Varnum, JM Jacobs, JG Pounds, RC Zangar, and A Shvedova. 2011. "Comparative Proteomics and Pulmonary Toxicity of Instilled Single Walled Carbon Nanotubes, Crocidolite Asbestos and Ultrafine Carbon Black in Mice." Toxicological Sciences 120(1):123-135. doi:10.1093/toxsci/kfq363 


  • Hinderliter PM, KR Minard, G Orr, WB Chrisler, BD Thrall, JG Pounds, and JG Teeguarden. 2010. "ISDD: A Computational Model of Particle Sedimentation, Diffusion and Target Cell Dosimetry for In Vitro Toxicity Studies." Particle and Fibre Toxicology 7(November):Article No. 36.  doi:10.1186/1743-8977-7-36


  • Crump KS, and JG Teeguarden. 2009. "Benchmark calculations from summarized data: an example." Environmental and Ecological Statistics 16(1):13-24. 
  • Waters KM, LM Masiello, RC Zangar, BJ Tarasevich, NJ Karin, RD Quesenberry, S Bandyopadhyay, JG Teeguarden, JG Pounds, and BD Thrall. 2009. "Macrophage Responses to Silica Nanoparticles are Highly Conserved Across Particle Sizes." Toxicological Sciences 107(2):553-569. 


  • Teeguarden JG, A Gupta, P Escobar, and M Jackson. 2008. "Toxicology steps up to nanotechnology safety." Research & Development 50(1):28-29. 
  • Teeguarden JG, MS Bogdanffy, TR Covington, C Tan, and AM Jarabek. 2008. "A PBPK Model for Evaluating the Impact of Aldehyde Dehydrogenase Polymorphisms on Comparative Rat and Human Nasal Tissue Acetaldehyde Dosimetry ." Inhalation Toxicology 20(4):375-390. doi:10.1080/08958370801903750


  • Teeguarden JG, DC Dorman, A Nong, TR Covington, HJ Clewell, III, and ME Andersen. 2007. "Pharmacokinetic Modeling of Manganese II. Hepatic Processing after Ingestion and Inhalation." Journal of Toxicology and Environmental Health Part A 70(18):1505-1514.  doi:10.1080/15287390701384619
  • Teeguarden JG, DC Dorman, TR Covington, HJ Clewell, III, and ME Andersen. 2007. "Pharmacokinetic Modeling of Manganese I. Dose-Dependencies of Uptake and Elimination." Journal of Toxicology and Environmental Health Part A 70(18):1493-1504. doi:10.1080/15287390701384601
  • Teeguarden JG, J Gearhart, HJ Clewell, III, TR Covington, A Nong, and ME Anderson. 2007. "Pharmacokinetic Modeling of Manganese III. Physiological Approaches Accounting for Background and Tracer Kinetics." Journal of Toxicology and Environmental Health Part A 70(18):1515-1526.  doi:10.1080/15287390701384635
  • Dutta D, SK Sundaram, JG Teeguarden, BJ Riley, LS Fifield, JM Jacobs, RS Addleman, GA Kaysen, BM Moudgil, and TJ Weber. 2007. "Adsorbed Proteins Influence the Biological Activity and Molecular Targeting of Nanomaterials." Toxicological Sciences 100(1):303-315. doi:10.1093/toxsci/kfm217 
  • Orr G, DJ Panther, JL Phillips, BJ Tarasevich, A Dohnalkova, D Hu, JG Teeguarden, and JG Pounds. 2007. "Submicron and Nanoscale Inorganic Particles Exploit the Actin Machinery to be Propelled Along Microvillilike Structures into Alveolar Cells." ACS Nano 1(5):463-475. doi:10.1021/nn700149r
  • Teeguarden JG, PM Hinderliter, G Orr, BD Thrall, and JG Pounds. 2007. "Particokinetics In Vitro: Dosimetry Considerations for In Vitro Nanoparticle Toxicity Assessments." Toxicological Sciences 95(2):300-312.  doi:10.1093/toxsci/kfl165


  • Teeguarden JG, JM Waechter, HJ Clewell, III, TR Covington, and HA Barton. 2005. "Evaluation of Oral and IntravenousRoute Pharmacokinetics, Plasma Protein Binding and Uterine Tissue Dose Metrics of Bisphenol A: A Physiologically Based Pharmacokinetic Approach." Toxicological Sciences 85(2):823-838.  doi:10.1093/toxsci/kfil135
  • Teeguarden JG, PJ Deisinger, TS Poet, JC English, WD Faber, HA Barton, RA Corley, and HJ Clewell, III. 2005. " Derivation of a human equivalent concentration for n-butanol using a physiologically based pharmacokinetic model for n-butyl acetate and metabolites n-butanol and n-butyric acid ." Toxicological Sciences 85(1):429-446. 
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