U.S. Department of Energy

Pacific Northwest National Laboratory

Jason Wendler

Jason Wendler
Professional Title: 
Scientist
Email: 
jason.wendler@pnnl.gov
Biography: 

Jason is interested in the molecular pathogenesis that underlies poor clinical outcomes in viral and protozoan infectious diseases.  His current research uses cutting-edge methods in machine learning and graph analytics to translate multi-omic data into insights about the host response to lethal infection, most recently focused on understanding severe outcomes in dengue, Zika, and Ebola virus infections.  Dr. Wendler also leads a PNNL effort to utilize advances in hypergraph theory for big-data biomedicine, and holds a Guest Scientist appointment with the National Institutes of Health (NIH). 

Dr. Wendler received his post-graduate training in Genomic Medicine and Statistics in the Nuffield Department of Clinical Medicine at Oxford University.  He studied human and malaria parasite genetics under Dominic Kwiatkowski, M.D., FRS, at the Wellcome Trust Centre for Human Genetics and at Sanger.  As an NIH fellow under Patrick Duffy, M.D., Jason worked and taught extensively in East and West Africa, investigating severe malaria in children and during pregnancy.

Education: 
  • DPhil, Genomic Medicine and Statistics, Oxford
  • M.Sc., Statistics, University of Nebraska
  • B.Sc., Microbiology, Middle Tennessee State University
Awards: 
  • National Research Service Award, NIH/NINDS
  • Intramural Research Training Award, NIH/NIAID/LMIV
  • Oxford Genomic Medicine studentship, UK Wellcome Trust
  • Clinical research LRP award, NIH/NIAID
  • Life Sciences Interdisciplinary Graduate Recruitment Program (LSIGRP) award, UNL
  • Institutional National Science Foundation fellowship, UNL
Research Interests: 
  • Graph theory, hypergraphs, topological data analysis, sheaf theory
  • Statistical/machine-learning methods for data fusion and biomarker discovery
  • Genomic epidemiology and population genetics
  • Host-pathogen interactions
Publications: 

* Co-first authorship

Papers

  • Kedia K, Wendler JP*, et al.  Application of Multiplexed Ion Mobility Spectrometry towards the Identification of Host Protein Signatures of Treatment Effect in Pulmonary Tuberculosis. Tuberculosis (accepted).
  • Eisfeld AJ, P Halfmann, JP Wendler*, JE Kyle, KE Burnum-Johnson, Z Peralta, T Maemura, KB Walters, T Watanabe, S Fukuyama, M Yamashita, JM Jacobs, YM Kim, CP Casey, KG Stratton, BJM Webb-Robertson, MA Gritsenko, ME Monroe, KK Weitz, AK Shukla, M Tian, G Neumann, JL Reed, H van Bakel, TO Metz, RD Smith, KM Waters, A N'jai, F Sahr, and Y Kawaoka. 2017. "Multi-platform 'Omics Analysis of Human Ebola Virus Disease Pathogenesis." Cell Host & Microbe 22(6):817-829.  doi:10.1016/j.chom.2017.10.011
  • White RA, III, A Rivas-Ubach, MI Borkum, M Koberl, A Bilbao Pena, SM Colby, DW Hoyt, AK Bingol, YM Kim, JP Wendler, KK Hixson, and GC Jansson. 2017. "The state of rhizospheric science in the era of multi-omics: A practical guide to omics technologies." Rhizosphere 3(2):212-221.  doi:10.1016/j.rhisph.2017.05.003
  • White RA, III, MI Borkum, A Rivas-Ubach, A Bilbao Pena, JP Wendler, SM Colby, M Koberl, and GC Jansson. 2017. "From data to knowledge: The future of multi-omics data analysis for the rhizosphere." Rhizosphere 3(2):222-229.  doi:10.1016/j.rhisph.2017.05.001
  • Oxford KL, JP Wendler*, JE McDermott, RA White, III, JD Powell, JM Jacobs, JN Adkins, and KM Waters. 2016. "The Landscape of Viral Proteomics and Its Potential to Impact Human Health." Expert Review of Proteomics 13(6):579-591.  doi:10.1080/14789450.2016.1184091
  • Speake C, et al. Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates for Combination Vaccines with Circumsporozoite Protein. 2016. PloS One. PMID: 27434123.
  • Roberto Amato, et al. 2016. Genomic epidemiology of artemisinin resistant malaria. eLife 2016;5:e08714.
  • O’Brien JD, Iqbal Z, Wendler JP, Amenga-Etego L.  2016.  Inferring strain mixture within clinical Plasmodium falciparum isolates from genomic sequence data. PLoS Computational Biology. PMCID: PMC4928962.
  • Wendler JP*, Okombo J, Amato R, Miotto O, Kiara SM, et al. 2014. A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya. PloS One. PMCID: PMC4014544.
  • Taylor R, Kebaara BW, Nazarenus T, Jones A, Yamanaka R, Uhrenholdt R, Wendler JP, Atkin AL et al. 2005. Gene set coregulated by the Saccharomyces cerevisiae nonsense-mediated mRNA decay pathway. Eukaryotic cell 4: 2066-2077. PMCID: PMC1317485.
  • Francis SE, Malkov VA, Oleinikov AV, Rossnagle E, Wendler JP, et al. 2007. Six genes are preferentially transcribed by the circulating and sequestered forms of Plasmodium falciparum parasites that infect pregnant women. Infection and immunity. PMCID: PMC2044550.
  • Fried M, Wendler JP, Mutabingwa TK, Duffy PE. 2004. Mass spectrometric analysis of Plasmodium falciparum erythrocyte membrane protein-1 variants expressed by placental malaria parasites. Proteomics. PMID: 15048989.

Patents

  • Duffy PE, Kappe S, Krzych U, Heppner D, Bergman LW, Malkov V, Tarun A, Wendler JP, Bacik I. 2012. Liver stage antigens. Patent number: 8318183.
  • Fried M, Duffy PE, Francis S, Wendler JP, Mutabingwa TK, Oleinikov A. 2011. Malaria vaccines. Patent number: 8012493.
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