U.S. Department of Energy

Pacific Northwest National Laboratory

Geremy Clair

Geremy Clair
Professional Title: 
Scientist
Phone Number: 
(509) 371-7240
Email: 
geremy.clair@pnnl.gov
Biography: 

Dr. Clair’s educational background, research, teaching interests and experience are strongly interdisciplinary. His graduate work and teaching experience were in multi-omics analysis, Lung biology, microbiology, and biochemistry. After his graduation in France, He completed performed two post-doctorates using a combination of omics technologies, bioinformatics, and biochemistry. 

Dr. Clair is involved in a wide variety of projects including projects dealing with Lung pediatric biology, the development of tools to achieve omics measurements from extremely small samples including single mammalian cells proteomics, and the study of bacterial pathogens:

  • He is multi-PI of a Research Center of the LungMAP consortium Omics, a large project funded by NHLBI (National Heart, Lung, and Blood Institute, NIH). The overarching goal of this initiative is to create a molecular atlas of the developing lung to serve as a research resource and public education tool. The LungMAP project allows researchers to explore the spatio-temporal molecular atlas of the normal and diseased developing lung (e.g., Cystic Fibrosis, Bronchio Pulmonary Dysplasia, etc.). In this context, he has been leading, co-leading author, and key contributor of several publications. Specifically, he has participated in: (i) the development of technologies enabling to quantify the proteins contained in small tissue samples at scales unattainable before, including microdissected tissue section of less than 4000 cells and single-cell samples ; (ii) the description of the dynamics of thousands of protein and lipids in during the process of  lung development; and (iii) the elucidation of essential processes in the production of lung surfactant an essential fluid that allows respiration; and in the development of tools facilitating lipid analysis.
  • Dr. Clair has developed new innovative technologies and strategies to analyze proteins in minute samples including small microdissected functional units such as lung alveolar tissue or single kidney glomeruli.
  • Dr. Clair has bioinformatic R packages and shiny apps to perform functional enrichment analysis of lipids (e.g., Lipid Mini-On) and to analyze reproducibly omics dataset (e.g., RomicsProcessor)
  • Dr. Clair has described how the pathogens of the group Bacillus cereus were regulating the expression of their virulence factors in response to redox variations found in their host environment, demonstrated how the foodborne pathogen Campylobacter jejuni was modulating its virulence program in response, elucidated the mode of action of Campylobacter secreted effector, participated to the first description of the mechanism by which the multi-resistant Staphylococcus aureus (MRSA) goes in a dormancy state called persister responsible for reoccurring infections.
Publications: 

2021

2020

2019

2018

2017

2016

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