U.S. Department of Energy

Pacific Northwest National Laboratory

Geremy Clair

Geremy Clair
Professional Title: 
Scientist
Phone Number: 
(509) 371-7240
Email: 
geremy.clair@pnnl.gov
Biography: 

Dr. Clair’s educational background, research, teaching interests and experience are strongly interdisciplinary. His graduate work and teaching experience were in multi-omics analysis, microbiology, molecular biology, and biochemistry. After his graduation in France, He completed performed two post-doctorates using a combination of omics technologies, bioinformatics, biochemistry and molecular biology. 

Dr. Clair is involved in a wide variety of projects including projects dealing with Lung pediatric biology, the development of tools to achieve omics measurements from extremely small samples, and the study of bacterial pathogens :

  • He is part of the lungMAP consortium, a large project funded by NHLBI (National Heart, Lung, and Blood Institute, NIH). The overarching goal of this initiative is to create a molecular atlas of the developing lung (LungMAP) to serve as a research resource and public education tool. It allows researchers to discover new mechanisms involved in the normal development of this organ, to better understand the functioning of rare respiratory diseases and of other lung diseases such as cystic fibrosis or Lung Cancer. In this context, he has been leading, co-leading author, and key contributor of several publications. Specifically, he has participated in: (i) the development of technologies enabling to quantify the proteins contained in small tissue samples at scales unattainable before, including samples smaller than 4000 cells and single cell samples ; (ii) the description of the dynamics of thousands of protein and lipids in during the process of  lung development; and (iii) the elucidation of essential processes in the production of lung surfactant an essential fluid that allows respiration; and in the development of tools facilitating lipid analysis.
  • Dr. Clair has developped new innovative technologies and strategies to analyse proteins in minute samples including small microdisscted functional units such as lung alveolar tissue or single kidney glomeruli. He is also one of the pionneer of the development of the strategies and the bioinformatics tools required for the unbiased measurement of protein abundance in single-cells.
  • Dr. Clair has described for the first time how the pathogens of the group Bacillus cereus were regulating the expression of their virulence factors in response to redox variations found in their host environement, demonstrated how the foodborne pathogen Campylobacter jejuni was modulating its virulence program in response to bile acid and to host cell extracellular factors and has participated to the first description of the mechanism by which the multi-resistant Staphylococcus aureus (MRSA) goes in a dormancy state called persister responsible for reoccuring infections.
Publications: 

2019

2018

2017

2016

| Pacific Northwest National Laboratory